Procrustes Analysis in Fetal Alcohol Syndrome diagnosis

Fetal Alcohol Syndrome

Background: About 40 thousand newborns are delivered annually with fetal alcohol syndrome (FAS). It induces serious CNS complications. Methods: In a review of, the word “fetal alcohol syndrome” was searched in PubMed and Google Scholar and the retrieved articles were summarized. Results: Many studies showed that alcohol can cause more defects in fetus than heroin, cocaine and marijuana. The pos...

Complications of Alcohol Use in Pregnancy

Background: Alcohol is a potent teratogen and alcohol use in pregnancy and the periconception period can cause many complications in mother, fetus and neonate.  Discussion: Alcohol in the mother's blood passes through the placenta to the baby through the umbilical cord. Drinking alcohol during pregnancy can cause miscarriage, stillbirth, and a range of lifelong disorders. Alcohol-related birth ...

Comparison of the 4-digit diagnostic code and the Hoyme diagnostic guidelines for fetal alcohol spectrum disorders.

OBJECTIVE The 4-Digit Diagnostic Code for fetal alcohol spectrum disorders and the Hoyme fetal alcohol spectrum disorders diagnostic guidelines differ markedly. The performances of the 2 diagnostic systems were compared. METHODS The fetal alcohol syndrome diagnostic criteria from the 4-Digit Code and Hoyme guidelines were applied to 952 patients who had received an interdisciplinary, fetal al...

Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis

PLGF, a placental marker of fetal brain defects after in utero alcohol exposure

Most children with in utero alcohol exposure do not exhibit all features of fetal alcohol syndrome (FAS), and a challenge for clinicians is to make an early diagnosis of fetal alcohol spectrum disorders (FASD) to avoid lost opportunities for care. In brain, correct neurodevelopment requires proper angiogenesis. Since alcohol alters brain angiogenesis and the placenta is a major source of angiog...